A review on covid-19: From molecular variability, drug development to status of vaccine clinical trials

A pandemic has erupted in all parts of the globe, originating from Wuhan province China December 2019. The virus was evaluated Coronaviridae family and Co ronaviridae subfamily, which showed homology with another spread across globe November 2002. It also pneumonia-like symptoms known as Severe Acute Respiratory Syndrome (SARS). SARS CoV-2 is new 2019 believed to show animal human transmission vice-versa. Many intermediate hosts should be included suitable for receptors. Finally, could have evolved due RNA recombination high frequency significant result plastic genome underpinning evolutionary forces CoVs. This resulted adaptation various by this different genotypes. In genome, there are 6-10 ORFs. Starting 2/3rd codes replicase protein part a fixed order structural genes (HE)-S-E-M-N. Human beings, first infects respiratory systems alveolar cells lungs. cellular receptor angiotensinconverting enzyme2 (ACE2). existing reviews mostly focus on specific areas COVID19. review gives comprehensive phylogeny analysis genetic makeup virus, making it target site scientists looking fair comparison. provides brief information mutation undergoing drugs being used stages drug development, vaccine its administration world, side effects vaccine, currently trending topics. We concentrated mainly diversifying our unique covering required information. would more beneficial researcher general reader understand COVID 19.